What is MK-677 (Ibutamoren)?MK-677 (Ibutamoren, MK-0677, L-163,191) is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth homone secretagogue, mimicking the growth homone (GH)-stimulating action of the endogenous homone ghrelin. It has been shown to increase the secretion of several homones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones without affecting cortisol levels.