40mg/Tablets Cat Fip Gs 441 Treatment For Fip Feline Infectious Peritonitis

PRODUCT DESCRIPTION GS-441524 Tablets For Feline Infectious Peritonitis Virus Treatment Product Description GS-441524 is an adenosine nucleotide analog antiviral, similar to remdesivi.This molecule was patented in 2009. In vitro studies of GS have determined it has a higher EC50 than remdesivi against a number of viruses, meaning GS is less potent.This medicine continues to be studied in the treatment of Feline Infectious Peritonitis Virus, that only infects cats. Appearance Tablets GS Standard 99.5%min Content 20mg/tablets, 40mg/tablets, or customized Application For CAT FIP R&D Use ONLY Recommended dosage 20 mg/kg How GS441524 Cures FIP If a cat's immune system is healthy and mature, the white blood cells should fight off an infection or virus, and allow the cat to build up an immune response, or antibodies. Cats who develop FIP have an immune defect or deficiency that causes the white blood cells to replicate, rather than fight, the virus. Essentially, the cats immune system is spreading the virus throughout the cat's body rather than trying to eliminate it. Cats who have no immune response develop wet FIP, while cats who have a partial immune response develop dry FIP. The nucleoside analog GS441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. In layman's terms, GS441524 interjects itself into the chain reaction and stops the replication of the virus. Pharmacodynamics GS-441524 nucleoside is phosphorylated with the aid of using nucleoside kinases (likely adenosine kinase (ADK), that is the enzyme that phosphorylates the structurally comparable ribavirin), after which phosphorylated once more with the aid of using nucleoside-diphosphate kinase (NDK) to the energetic nucleotide triphosphate form. The triphosphate of GS-441524, GS-443902, is likewise the bioactive anti-viral agent generated with the aid of using remdesivir, however is generated with the aid of using a extraordinary biochemical mechanism from the later. Mechanism of action Intracellular triple-phosphorylation of GS-441524 yields its energetic 1'-cyano-substituted adenosine triphosphate analogue, which immediately disrupts viral RNA replication with the aid of using competing with endogenous NTPs for incorporation into nascent viral RNA transcripts and triggering not on time chain termination of RNA-structured RNA polymerase. Tolerance In vitro experiments in Crandell Rees pussycat kidney (CRFK) cells observed GS-441524 become safe at a hundred µM concentrations, a hundred instances the dose powerful at inhibiting FIPV replication in cultured CRFK cells and inflamed macrophages. Clinical trials in cats imply the drug is well-tolerated, with the number one aspect impact being dermal inflammation from the acidity of the injection mix.