Quick Details
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- Brand Name:CR1 Polyclonal Antibody
Catalog number: E-AB-16356
Host: Rabbit
Applications: IHC, ELISA
Reactivity: H
Lead Time: 7-10 days
Synonyms KN, C3BR, C4BR, CD35
Swissprot P17927
Source Rabbit
Reactivity Human
Immunogen Synthetic peptide of human CR1
Application IHC,ELISA
Recommended dilution IHC 1:25-1:100
Concentration 1.4 mg/mL
Clonality Polyclonal
Properties
Isotype IgG
Purification Affinity purification
Conjugation Unconjugated
Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Background This gene is a member of the receptors of complement activation (RCA) family and is located in the
'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic
cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement.
Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and
sarcoidosis.